XTAR is a company that deals in USB rechargeable batteries among other things. In this case they asked if I was interested in reviewing their 4150mwh AA batteries and giving them a review. I agreed, but as these reviews take time, this is a running review of how they work for me.
TL;DR – running review last update August 5, 2024
In the past I had three USB rechargeable brands in a row that were, to put it nicely, not what was advertised. Each was filled to the brim with 5 star reviews talking about how much people were going to save but never any follow ups other than that they stopped working a couple of months in.
But, I tried USB rechargeable back in the early days, and also some relatively early consumer rechargeables, and my experiences were the same – worked for a couple of months and then I had spent $20 before they broke to replace $5 worth of standard batteries.
My experience with one USB rechargable battery manufacturer also showed me that attempting to get any after sale service (for 4 out of 8 batteries) was not worth it.
XTAR contacted me and asked if I wanted to try their 4150mwh USB rechargeable batteries and I figured why not? I’d love to see if rechargeable batteries have reached a point where they actually will pay for themselves, power my devices properly, and last as long as a normal.
What was in the box (August 5, 2024)
I received one XTAR Wall Adapter which is a Qualcomm 3.0 USB wall charger, 4xAA batteries and a charging dock for them.
While I don’t think you require the USB wall adapter, you do apparently require a USB output higher than my standing desk was providing and unfortunately I don’t have the specs on it handy at the moment. Batteries appeared to be charging and then the unit would shut off. Plugged it into the charger they sent and it seemed fine.
I believe the batteries were sent in a nearly charged state as charging did not take long. Only thing to really note here is that the indicators for charging (red) or charged (green) are difficult to discern at an angle.
Now to put them in things and see how they work…
On of my biggest gripes with rechargeables is that the ones I’ve had last about a week and are dead, so here goes… 2 in my utility flashlight, 2 in a kid’s toy. Flashlight light appears as bright as using my Amazon Basics AA batteries.
XTAR is a company that deals in USB rechargeable batteries among other things. In this case they asked if I was interested in reviewing their 4150mwh AA batteries and giving them a review. I agreed, but as these reviews take time, this is a running review of how they work for me.
TL;DR – running review last update August 5, 2024
In the past I had three USB rechargeable brands in a row that were, to put it nicely, not what was advertised. Each was filled to the brim with 5 star reviews talking about how much people were going to save but never any follow ups other than that they stopped working a couple of months in.
But, I tried USB rechargeable back in the early days, and also some relatively early consumer rechargeables, and my experiences were the same – worked for a couple of months and then I had spent $20 before they broke to replace $5 worth of standard batteries.
My experience with one USB rechargable battery manufacturer also showed me that attempting to get any after sale service (for 4 out of 8 batteries) was not worth it.
XTAR contacted me and asked if I wanted to try their 4150mwh USB rechargeable batteries and I figured why not? I’d love to see if rechargeable batteries have reached a point where they actually will pay for themselves, power my devices properly, and last as long as a normal.
What was in the box (August 5, 2024)
I received one XTAR Wall Adapter which is a Qualcomm 3.0 USB wall charger, 4xAA batteries and a charging dock for them.
While I don’t think you require the USB wall adapter, you do apparently require a USB output higher than my standing desk was providing and unfortunately I don’t have the specs on it handy at the moment. Batteries appeared to be charging and then the unit would shut off. Plugged it into the charger they sent and it seemed fine.
I believe the batteries were sent in a nearly charged state as charging did not take long. Only thing to really note here is that the indicators for charging (red) or charged (green) are difficult to discern at an angle.
Now to put them in things and see how they work…
On of my biggest gripes with rechargeables is that the ones I’ve had last about a week and are dead, so here goes… 2 in my utility flashlight, 2 in a kid’s toy. Flashlight light appears as bright as using my Amazon Basics AA batteries.
Senate hearings, a post office ban, the resignation of the director of the National Bureau of Standards, and his reinstatement after more than 400 scientists threatened to resign. Who knew a little box of salt could stir up such drama?
What was AD-X2?
It all started in 1947 when a bulldozer operator with a 6th grade education, Jess M. Ritchie, teamed up with UC Berkeley chemistry professor Merle Randall to promote AD-X2, an additive to extend the life of lead-acid batteries. The problem of these rechargeable batteries’ dwindling capacity was well known. If AD-X2 worked as advertised, millions of car owners would save money.
Jess M. Ritchie demonstrates his AD-X2 battery additive before the Senate Select Committee on Small Business.National Institute of Standards and Technology Digital Collections
A basic lead-acid battery has two electrodes, one of lead and the other of lead dioxide, immersed in dilute sulfuric acid. When power is drawn from the battery, the chemical reaction splits the acid molecules, and lead sulfate is deposited in the solution. When the battery is charged, the chemical process reverses, returning the electrodes to their original state—almost. Each time the cell is discharged, the lead sulfate “hardens” and less of it can dissolve in the sulfuric acid. Over time, it flakes off, and the battery loses capacity until it’s dead.
By the 1930s, so many companies had come up with battery additives that the U.S. National Bureau of Standards stepped in. Its lab tests revealed that most were variations of salt mixtures, such as sodium and magnesium sulfates. Although the additives might help the battery charge faster, they didn’t extend battery life. In May 1931, NBS (now the National Institute of Standards and Technology, or NIST) summarized its findings in Letter Circular No. 302: “No case has been found in which this fundamental reaction is materially altered by the use of these battery compounds and solutions.”
Of course, innovation never stops. Entrepreneurs kept bringing new battery additives to market, and the NBS kept testing them and finding them ineffective.
Do battery additives work?
After World War II, the National Better Business Bureau decided to update its own publication on battery additives, “Battery Compounds and Solutions.” The publication included a March 1949 letter from NBS director Edward Condon, reiterating the NBS position on additives. Prior to heading NBS, Condon, a physicist, had been associate director of research at Westinghouse Electric in Pittsburgh and a consultant to the National Defense Research Committee. He helped set up MIT’s Radiation Laboratory, and he was also briefly part of the Manhattan Project. Needless to say, Condon was familiar with standard practices for research and testing.
Meanwhile, Ritchie claimed that AD-X2’s secret formula set it apart from the hundreds of other additives on the market. He convinced his senator, William Knowland, a Republican from Oakland, Calif., to write to NBS and request that AD-X2 be tested. NBS declined, not out of any prejudice or ill will, but because it tested products only at the request of other government agencies. The bureau also had a longstanding policy of not naming the brands it tested and not allowing its findings to be used in advertisements.
AD-X2 consisted mainly of Epsom salt and Glauber’s salt.National Institute of Standards and Technology Digital Collections
Ritchie cried foul, claiming that NBS was keeping new businesses from entering the marketplace. Merle Randall launched an aggressive correspondence with Condon and George W. Vinal, chief of NBS’s electrochemistry section, extolling AD-X2 and the testimonials of many users. In its responses, NBS patiently pointed out the difference between anecdotal evidence and rigorous lab testing.
Enter the Federal Trade Commission. The FTC had received a complaint from the National Better Business Bureau, which suspected that Pioneers, Inc.—Randall and Ritchie’s distribution company—was making false advertising claims. On 22 March 1950, the FTC formally asked NBS to test AD-X2.
By then, NBS had already extensively tested the additive. A chemical analysis revealed that it was 46.6 percent magnesium sulfate (Epsom salt) and 49.2 percent sodium sulfate (Glauber’s salt, a horse laxative) with the remainder being water of hydration (water that’s been chemically treated to form a hydrate). That is, AD-X2 was similar in composition to every other additive on the market. But, because of its policy of not disclosing which brands it tests, NBS didn’t immediately announce what it had learned.
The David and Goliath of battery additives
NBS then did something unusual: It agreed to ignore its own policy and let the National Better Business Bureau include the results of its AD-X2 tests in a public statement, which was published in August 1950. The NBBB allowed Pioneers to include a dissenting comment: “These tests were not run in accordance with our specification and therefore did not indicate the value to be derived from our product.”
Far from being cowed by the NBBB’s statement, Ritchie was energized, and his story was taken up by the mainstream media. Newsweek’s coverage pitted an up-from-your-bootstraps David against an overreaching governmental Goliath. Trade publications, such as Western Construction News and Batteryman, also published flattering stories about Pioneers. AD-X2 sales soared.
Then, in January 1951, NBS released its updated pamphlet on battery additives, Circular 504. Once again, tests by the NBS found no difference in performance between batteries treated with additives and the untreated control group. The Government Printing Office sold the circular for 15 cents, and it was one of NBS’s most popular publications. AD-X2 sales plummeted.
Ritchie needed a new arena in which to challenge NBS. He turned to politics. He called on all of his distributors to write to their senators. Between July and December 1951, 28 U.S. senators and one U.S. representative wrote to NBS on behalf of Pioneers.
Condon was losing his ability to effectively represent the Bureau. Although the Senate had confirmed Condon’s nomination as director without opposition in 1945, he was under investigation by the House Committee on Un-American Activities for several years. FBI Director J. Edgar Hoover suspected Condon to be a Soviet spy. (To be fair, Hoover suspected the same of many people.) Condon was repeatedly cleared and had the public backing of many prominent scientists.
But Condon felt the investigations were becoming too much of a distraction, and so he resigned on 10 August 1951. Allen V. Astin became acting director, and then permanent director the following year. And he inherited the AD-X2 mess.
Astin had been with NBS since 1930. Originally working in the electronics division, he developed radio telemetry techniques, and he designed instruments to study dielectric materials and measurements. During World War II, he shifted to military R&D, most notably development of the proximity fuse, which detonates an explosive device as it approaches a target. I don’t think that work prepared him for the political bombs that Ritchie and his supporters kept lobbing at him.
Mr. Ritchie almost goes to Washington
On 6 September 1951, another government agency entered the fray. C.C. Garner, chief inspector of the U.S. Post Office Department, wrote to Astin requesting yet another test of AD-X2. NBS dutifully submitted a report that the additive had “no beneficial effects on the performance of lead acid batteries.” The post office then charged Pioneers with mail fraud, and Ritchie was ordered to appear at a hearing in Washington, D.C., on 6 April 1952. More tests were ordered, and the hearing was delayed for months.
Back in March 1950, Ritchie had lost his biggest champion when Merle Randall died. In preparation for the hearing, Ritchie hired another scientist: Keith J. Laidler, an assistant professor of chemistry at the Catholic University of America. Laidler wrote a critique of Circular 504, questioning NBS’s objectivity and testing protocols.
Ritchie also got Harold Weber, a professor of chemical engineering at MIT, to agree to test AD-X2 and to work as an unpaid consultant to the Senate Select Committee on Small Business.
Life was about to get more complicated for Astin and NBS.
Why did the NBS Director resign?
Trying to put an end to the Pioneers affair, Astin agreed in the spring of 1952 that NBS would conduct a public test of AD-X2 according to terms set by Ritchie. Once again, the bureau concluded that the battery additive had no beneficial effect.
However, NBS deviated slightly from the agreed-upon parameters for the test. Although the bureau had a good scientific reason for the minor change, Ritchie had a predictably overblown reaction—NBS cheated!
Then, on 18 December 1952, the Senate Select Committee on Small Business—for which Ritchie’s ally Harold Weber was consulting—issued a press release summarizing the results from the MIT tests: AD-X2 worked! The results “demonstrate beyond a reasonable doubt that this material is in fact valuable, and give complete support to the claims of the manufacturer.” NBS was “simply psychologically incapable of giving Battery AD-X2 a fair trial.”
The National Bureau of Standards’ regular tests of battery additives found that the products did not work as claimed.National Institute of Standards and Technology Digital Collections
But the press release distorted the MIT results.The MIT tests had focused on diluted solutions and slow charging rates, not the normal use conditions for automobiles, and even then AD-X2’s impact was marginal. Once NBS scientists got their hands on the report, they identified the flaws in the testing.
How did the AD-X2 controversy end?
The post office finally got around to holding its mail fraud hearing in the fall of 1952. Ritchie failed to attend in person and didn’t realize his reports would not be read into the record without him, which meant the hearing was decidedly one-sided in favor of NBS. On 27 February 1953, the Post Office Department issued a mail fraud alert. All of Pioneers’ mail would be stopped and returned to sender stamped “fraudulent.” If this charge stuck, Ritchie’s business would crumble.
But something else happened during the fall of 1952: Dwight D. Eisenhower, running on a pro-business platform, was elected U.S. president in a landslide.
Ritchie found a sympathetic ear in Eisenhower’s newly appointed Secretary of Commerce Sinclair Weeks, who acted decisively. The mail fraud alert had been issued on a Friday. Over the weekend, Weeks had a letter hand-delivered to Postmaster General Arthur Summerfield, another Eisenhower appointee. By Monday, the fraud alert had been suspended.
What’s more, Weeks found that Astin was “not sufficiently objective” and lacked a “business point of view,” and so he asked for Astin’s resignation on 24 March 1953. Astin complied. Perhaps Weeks thought this would be a mundane dismissal, just one of the thousands of political appointments that change hands with every new administration. That was not the case.
More than 400 NBS scientists—over 10 percent of the bureau’s technical staff— threatened to resign in protest. The American Academy for the Advancement of Science also backed Astin and NBS. In an editorial published in Science, the AAAS called the battery additive controversy itself “minor.” “The important issue is the fact that the independence of the scientist in his findings has been challenged, that a gross injustice has been done, and that scientific work in the government has been placed in jeopardy,” the editorial stated.
National Bureau of Standards director Edward Condon [left] resigned in 1951 because investigations into his political beliefs were impeding his ability to represent the bureau. Incoming director Allen V. Astin [right] inherited the AD-X2 controversy, which eventually led to Astin’s dismissal and then his reinstatement after a large-scale protest by NBS researchers and others. National Institute of Standards and Technology Digital Collections
Clearly, AD-X2’s effectiveness was no longer the central issue. The controversy was a stand-in for a larger debate concerning the role of government in supporting small business, the use of science in making policy decisions, and the independence of researchers. Over the previous few years, highly respected scientists, including Edward Condon and J. Robert Oppenheimer, had been repeatedly investigated for their political beliefs. The request for Astin’s resignation was yet another government incursion into scientific freedom.
Weeks, realizing his mistake, temporarily reinstated Astin on 17 April 1953, the day the resignation was supposed to take effect. He also asked the National Academy of Sciences to test AD-X2 in both the lab and the field. By the time the academy’s report came out in October 1953, Weeks had permanently reinstated Astin. The report, unsurprisingly, concluded that NBS was correct: AD-X2 had no merit. Science had won.
NIST makes a movie
On 9 December 2023, NIST released the 20-minute docudrama The AD-X2 Controversy. The film won the Best True Story Narrative and Best of Festival at the 2023 NewsFest Film Festival. I recommend taking the time to watch it.
Many of the actors are NIST staff and scientists, and they really get into their roles. Much of the dialogue comes verbatim from primary sources, including congressional hearings and contemporary newspaper accounts.
Despite being an in-house production, NIST’s film has a Hollywood connection. The film features brief interviews with actors John and Sean Astin (of Lord of The Rings and Stranger Things fame)—NBS director Astin’s son and grandson.
The AD-X2 controversy is just as relevant today as it was 70 years ago. Scientific research, business interests, and politics remain deeply entangled. If the public is to have faith in science, it must have faith in the integrity of scientists and the scientific method. I have no objection to science being challenged—that’s how science moves forward—but we have to make sure that neither profit nor politics is tipping the scales.
Part of a continuing serieslooking at historical artifacts that embrace the boundless potential of technology.
An abridged version of this article appears in the August 2024 print issue as “The AD-X2 Affair.”
References
I first heard about AD-X2 after my IEEE Spectrum editor sent me a notice about NIST’s short docudrama The AD-X2 Controversy, which you can, and should, stream online. NIST held a colloquium on 31 July 2018 with John Astin and his brother Alexander (Sandy), where they recalled what it was like to be college students when their father’s reputation was on the line. The agency has also compiled a wonderful list of resources, including many of the primary source government documents.
The AD-X2 controversy played out in the popular media, and I read dozens of articles following the almost daily twists and turns in the case in the New York Times, Washington Post, and Science.
Earlier this month, China announced that it is pouring 6 billion yuan (about US $826 million) into a fund meant to spur the development of solid-state batteries by the nation’s leading battery manufacturers. Solid-state batteries use electrolytes of either glass, ceramic, or solid polymer material instead of the liquid lithium salts that are in the vast majority of today’s electric vehicle (EV) batteries. They’re greatly anticipated because they will have three or four times as much energy density as batteries with liquid electrolytes, offer more charge-discharge cycles over their lifetimes, and be far less susceptible to the thermal runaway reaction that occasionally causes lithium batteries to catch fire.
But China’s investment in the future of batteries won’t likely speed up the timetable for mass production and use in production vehicles. As IEEE Spectrumpointed out in January, it’s not realistic to look for solid-state batteries in production vehicles anytime soon. Experts Spectrum consulted at the time “noted a pointed skepticism toward the technical merits of these announcements. None could isolate anything on the horizon indicating that solid-state technology can escape the engineering and ‘production hell’ that lies ahead.”
“To state at this point that any one battery and any one country’s investments in battery R&D will dominate in the future is simply incorrect.” —Steve W. Martin, Iowa State University
Reaching scale production of solid-state batteries for EVs will first require validating existing solid-state battery technologies—now being used for other, less demanding applications—in terms of performance, life-span, and relative cost for vehicle propulsion. Researchers must still determine how those batteries take and hold a charge and deliver power as they age. They’ll also need to provide proof that a glass or ceramic battery can stand up to the jarring that comes with driving on bumpy roads and certify that it can withstand the occasional fender bender.
Here Come Semi-Solid-State Batteries
Meanwhile, as the world waits for solid electrolytes to shove liquids aside, Chinese EV manufacturer Nio and battery maker WeLion New Energy Technology Co. have partnered to stake a claim on the market for a third option that splits the difference: semi-solid-state batteries, with gel electrolytes.
CarNewsChina.com reported in April that the WeLion cells have an energy density of 360 watt-hours per kilogram. Fully packaged, the battery’s density rating is 260 Wh/kg. That’s still a significant improvement over lithium iron phosphate batteries, whose density tops out at 160 Wh/kg. In tests conducted last month with Nio’s EVs in Shanghai, Chengdu, and several other cities, the WeLion battery packs delivered more than 1,000 kilometers of driving range on a single charge. Nio says it plans to roll out the new battery type across its vehicle lineup beginning this month.
But the Beijing government’s largesse and the Nio-WeLion partnership’s attempt to be first to get semi-solid-state batteries into production vehicles shouldn’t be a temptation to call the EV propulsion game prematurely in China’s favor.
So says Steve W. Martin, a professor of materials science and engineering at Iowa State University, in Ames. Martin, whose research areas include glassy solid electrolytes for solid-state lithium batteries and high-capacity reversible anodes for lithium batteries, believes that solid-state batteries are the future and that hybrid semi-solid batteries will likely be a transition between liquid and solid-state batteries. However, he says, “to state at this point that any one battery and any one country’s investments in battery R&D will dominate in the future is simply incorrect.” Martin explains that “there are too many different kinds of solid-state batteries being developed right now and no one of these has a clear technological lead.”
The Advantages of Semi-Solid-State Batteries
The main innovation that gives semi-solid-state batteries an advantage over conventional batteries is the semisolid electrolyte from which they get their name. The gel electrolyte contains ionic conductors such as lithium salts just as liquid electrolytes do, but the way they are suspended in the gel matrix supports much more efficient ion conductivity. Enhanced transport of ions from one side of the battery to the other boosts the flow of current in the opposite direction that makes a complete circuit. This is important during the charging phase because the process happens more rapidly than it can in a battery with a liquid electrolyte. The gel’s structure also resists the formation of dendrites, the needlelike structures that can form on the anode during charging and cause short circuits. Additionally, gels are less volatile than liquid electrolytes and are therefore less prone to catching fire.
Though semi-solid-state batteries won’t reach the energy densities and life-spans that are expected from those with solid electrolytes, they’re at an advantage in the short term because they can be made on conventional lithium-ion battery production lines. Just as important, they have been tested and are available now rather than at some as yet unknown date.
Semi-solid-state batteries can be made on conventional lithium-ion battery production lines.
Several companies besides WeLion are actively developing semi-solid-state batteries. China’s prominent battery manufacturers, including CATL, BYD, and the state-owned automakers FAW Group and SAIC Group are, like WeLion, beneficiaries of Beijing’s plans to advance next-generation battery technology domestically. Separately, the startup Farasis Energy, founded in Ganzhou, China, in 2009, is collaborating with Mercedes-Benz to commercialize advanced batteries.
The Road Forward to Solid-State Batteries
U.S. startup QuantumScape says the solid-state lithium metal batteries it’s developing will offer energy density of around 400 Wh/kg. The company notes that its cells eliminate the charging bottleneck that occurs in conventional lithium-ion cells, where lithium must diffuse into the carbon particles. QuantumScape’s advanced batteries will therefore allow fast charging from 10 to 80 percent in 15 minutes. That’s a ways off, but the Silicon Valley–based company announced in March that it had begun shipping its prototype Alpha-2 semi-solid-state cells to manufacturers for testing.
Toyota is among a group of companies not looking to hedge their bets. The automaker, ignoring naysayers, aims to commercialize solid-state batteries by 2027 that it says will give an EV a range of 1,200 km on a single charge and allow 10-minute fast charging. It attributes its optimism to breakthroughs addressing durability issues. And for companies like Solid Power, it’s also solid-state or bust. Solid Power, which aims to commercialize a lithium battery with a proprietary sulfide-based solid electrolyte, has partnered with major automakers Ford and BMW. ProLogium Technology, which is also forging ahead with preparations for a solid-state battery rollout, claims that it will start delivering batteries this year that combine a ceramic oxide electrolyte with a lithium-free soft cathode (for energy density exceeding 500 Wh/kg). The company, which has teamed up with Mercedes-Benz, demonstrated confidence in its timetable by opening the world’s first giga-level solid-state lithium ceramic battery factory earlier this year in Taoyuan, Taiwan.
“How do we get to making nanomaterials that haven’t been evolved before?” asked Angela Belcher at the 2023 Mildred S. Dresselhaus Lecture at MIT on Nov. 20. “We can use elements that biology has already given us.”
The combined in-person and virtual audience of over 300 was treated to a light-up, 3D model of M13 bacteriophage, a virus that only infects bacteria, complete with a pull-out strand of DNA. Belcher used the feather-boa-like model to show how her research group modifies the M13’s genes to add new DNA and peptide sequences to template inorganic materials.
“I love controlling materials at the nanoscale using biology,” said Belcher, the James Mason Crafts Professor of Biological Engineering, materials science professor, and of the Koch Institute of Integrative Cancer Research at MIT. “We all know if you control materials at the nanoscale and you can start to tune them, then you can have all kinds of different applications.” And the opportunities are indeed vast — from building batteries, fuel cells, and solar cells to carbon sequestration and storage, environmental remediation, catalysis, and medical diagnostics and imaging.
Belcher sprinkled her talk with models and props, lined up on a table at the front of the 10-250 lecture hall, to demonstrate a wide variety of concepts and projects made possible by the intersection of biology and nanotechnology.
Energy storage and environment
“How do you go from a DNA sequence to a functioning battery?” posed Belcher. Grabbing a model of a large carbon nanotube, she explained how her group engineered a phage to pick up carbon nanotubes that would wind all the way around the virus and then fill in with different cathode or anode materials to make nanowires for battery electrodes.
How about using the M13 bacteriophage to improve the environment? Belcher referred to a project by former student Geran Zhang PhD ’19 that proved the virus can be modified for this context, too. He used the phage to template high-surface-area, carbon-based materials that can grab small molecules and break them down, Belcher said, opening a realm of possibilities from cleaning up rivers to developing chemical warfare agents to combating smog.
Belcher’s lab worked with the U.S. Army to produce protective clothing and masks made of these carbon-based virus nanofibers. “We went from five liters in our lab to a thousand liters, then 10,000 liters in the army labs where we’re able to make kilograms of the material,” Belcher said, stressing the importance of being able to test and prototype at scale.
Imaging tools and therapeutics in cancer
In the area of biomedical imaging, Belcher explained, a lot less is known in near-infrared imaging — imaging in wavelengths above 1,000 nanometers — than other imaging techniques, yet with near-infrared scientists can see much deeper inside the body. Belcher’s lab built their own systems to image at these wavelengths. The third generation of this system provides real-time, sub-millimeter optical imaging for guided surgery.
Working with Sangeeta Bhatia, the John J. and Dorothy Wilson Professor of Engineering, Belcher used carbon nanotubes to build imaging tools that find tiny tumors during surgery that doctors otherwise would not be able to see. The tool is actually a virus engineered to carry with it a fluorescent, single-walled carbon nanotube as it seeks out the tumors.
Nearing the end of her talk, Belcher presented a goal: to develop an accessible detection and diagnostic technology for ovarian cancer in five to 10 years.
“We think that we can do it,” Belcher said. She described her students’ work developing a way to scan an entire fallopian tube, as opposed to just one small portion, to find pre-cancer lesions, and talked about the team of MIT faculty, doctors, and researchers working collectively toward this goal.
“Part of the secret of life and the meaning of life is helping other people enjoy the passage of time,” said Belcher in her closing remarks. “I think that we can all do that by working to solve some of the biggest issues on the planet, including helping to diagnose and treat ovarian cancer early so people have more time to spend with their family.”
Honoring Mildred S. Dresselhaus
Belcher was the fifth speaker to deliver the Dresselhaus Lecture, an annual event organized by MIT.nano to honor the late MIT physics and electrical engineering Institute Professor Mildred Dresselhaus. The lecture features a speaker from anywhere in the world whose leadership and impact echo Dresselhaus’s life, accomplishments, and values.
“Millie was and is a huge hero of mine,” said Belcher. “Giving a lecture in Millie’s name is just the greatest honor.”
Belcher dedicated the talk to Dresselhaus, whom she described with an array of accolades — a trailblazer, a genius, an amazing mentor, teacher, and inventor. “Just knowing her was such a privilege,” she said.
Belcher also dedicated her talk to her own grandmother and mother, both of whom passed away from cancer, as well as late MIT professors Susan Lindquist and Angelika Amon, who both died of ovarian cancer.
“I’ve been so fortunate to work with just the most talented and dedicated graduate students, undergraduate students, postdocs, and researchers,” concluded Belcher. “It has been a pure joy to be in partnership with all of you to solve these very daunting problems.”
Professor Angela Belcher pulls a single strand of DNA out of a light-up model of M13 bacteriophage, a virus that only infects bacteria. Belcher’s lab modifies the M13’s genes to add new DNA and peptide sequences to template inorganic materials.
“How do we get to making nanomaterials that haven’t been evolved before?” asked Angela Belcher at the 2023 Mildred S. Dresselhaus Lecture at MIT on Nov. 20. “We can use elements that biology has already given us.”
The combined in-person and virtual audience of over 300 was treated to a light-up, 3D model of M13 bacteriophage, a virus that only infects bacteria, complete with a pull-out strand of DNA. Belcher used the feather-boa-like model to show how her research group modifies the M13’s genes to add new DNA and peptide sequences to template inorganic materials.
“I love controlling materials at the nanoscale using biology,” said Belcher, the James Mason Crafts Professor of Biological Engineering, materials science professor, and of the Koch Institute of Integrative Cancer Research at MIT. “We all know if you control materials at the nanoscale and you can start to tune them, then you can have all kinds of different applications.” And the opportunities are indeed vast — from building batteries, fuel cells, and solar cells to carbon sequestration and storage, environmental remediation, catalysis, and medical diagnostics and imaging.
Belcher sprinkled her talk with models and props, lined up on a table at the front of the 10-250 lecture hall, to demonstrate a wide variety of concepts and projects made possible by the intersection of biology and nanotechnology.
Energy storage and environment
“How do you go from a DNA sequence to a functioning battery?” posed Belcher. Grabbing a model of a large carbon nanotube, she explained how her group engineered a phage to pick up carbon nanotubes that would wind all the way around the virus and then fill in with different cathode or anode materials to make nanowires for battery electrodes.
How about using the M13 bacteriophage to improve the environment? Belcher referred to a project by former student Geran Zhang PhD ’19 that proved the virus can be modified for this context, too. He used the phage to template high-surface-area, carbon-based materials that can grab small molecules and break them down, Belcher said, opening a realm of possibilities from cleaning up rivers to developing chemical warfare agents to combating smog.
Belcher’s lab worked with the U.S. Army to produce protective clothing and masks made of these carbon-based virus nanofibers. “We went from five liters in our lab to a thousand liters, then 10,000 liters in the army labs where we’re able to make kilograms of the material,” Belcher said, stressing the importance of being able to test and prototype at scale.
Imaging tools and therapeutics in cancer
In the area of biomedical imaging, Belcher explained, a lot less is known in near-infrared imaging — imaging in wavelengths above 1,000 nanometers — than other imaging techniques, yet with near-infrared scientists can see much deeper inside the body. Belcher’s lab built their own systems to image at these wavelengths. The third generation of this system provides real-time, sub-millimeter optical imaging for guided surgery.
Working with Sangeeta Bhatia, the John J. and Dorothy Wilson Professor of Engineering, Belcher used carbon nanotubes to build imaging tools that find tiny tumors during surgery that doctors otherwise would not be able to see. The tool is actually a virus engineered to carry with it a fluorescent, single-walled carbon nanotube as it seeks out the tumors.
Nearing the end of her talk, Belcher presented a goal: to develop an accessible detection and diagnostic technology for ovarian cancer in five to 10 years.
“We think that we can do it,” Belcher said. She described her students’ work developing a way to scan an entire fallopian tube, as opposed to just one small portion, to find pre-cancer lesions, and talked about the team of MIT faculty, doctors, and researchers working collectively toward this goal.
“Part of the secret of life and the meaning of life is helping other people enjoy the passage of time,” said Belcher in her closing remarks. “I think that we can all do that by working to solve some of the biggest issues on the planet, including helping to diagnose and treat ovarian cancer early so people have more time to spend with their family.”
Honoring Mildred S. Dresselhaus
Belcher was the fifth speaker to deliver the Dresselhaus Lecture, an annual event organized by MIT.nano to honor the late MIT physics and electrical engineering Institute Professor Mildred Dresselhaus. The lecture features a speaker from anywhere in the world whose leadership and impact echo Dresselhaus’s life, accomplishments, and values.
“Millie was and is a huge hero of mine,” said Belcher. “Giving a lecture in Millie’s name is just the greatest honor.”
Belcher dedicated the talk to Dresselhaus, whom she described with an array of accolades — a trailblazer, a genius, an amazing mentor, teacher, and inventor. “Just knowing her was such a privilege,” she said.
Belcher also dedicated her talk to her own grandmother and mother, both of whom passed away from cancer, as well as late MIT professors Susan Lindquist and Angelika Amon, who both died of ovarian cancer.
“I’ve been so fortunate to work with just the most talented and dedicated graduate students, undergraduate students, postdocs, and researchers,” concluded Belcher. “It has been a pure joy to be in partnership with all of you to solve these very daunting problems.”
Professor Angela Belcher pulls a single strand of DNA out of a light-up model of M13 bacteriophage, a virus that only infects bacteria. Belcher’s lab modifies the M13’s genes to add new DNA and peptide sequences to template inorganic materials.
American federalism is struggling. Federal rules are an overwhelming presence in every state government, and some states, due to their size or other leverage, can impose their own policies on much or all of the country. The problem has been made clearer by an under-the-radar plan to phase out diesel locomotives in California. If the federal government provides the state with a helping hand, it would bring nationwide repercussions for a vital, overlooked industry.
Various industry and advocacy groups are lining up against California's costly measure, calling on the U.S. Environmental Protection Agency (EPA) to deny a waiver needed to fully implement it. In the past month, more than 30 leading conservative organizations and individuals, hundreds of state and local chambers of commerce, and the U.S. agricultural sector have pleaded with the EPA to help stop this piece of extremism from escaping one coastal state.
Railroads may not be something most Americans, whose attention is on their own cars and roads, think about often. But rail is the most basic infrastructure of interstate commerce, accounting for around 40 percent of long-distance ton-miles. It's also fairly clean, accounting for less than 1 percent of total U.S. emissions. Private companies, like Union Pacific in the West or CSX in the East, pay for their infrastructure and equipment. These facts haven't stopped the regulatory power grab.
Most importantly, the California Air Resources Board (CARB) regulation would have all freight trains operate in zero-emission configuration by 2035. At the end of the decade, the state is mandating the retirement of diesel locomotives 23 years or older, despite typically useful lives of over 40 years. Starting in 2030, new passenger locomotives must operate with zero emissions, with new engines for long-haul freight trains following by 2035. It limits locomotive idling and increases reporting requirements.
Given the interstate nature of railway operations, California needs the EPA to grant a waiver. If the agency agrees, the policy will inevitably affect the entire continental United States.
The kicker is that no technology exists today to enable railroads to comply with California's diktat, rendering the whole exercise fanciful at best.
The Wall Street Journal's editorial board explained last November that while Wabtec Corp. has introduced a pioneering advance in rail technology with the launch of the world's first battery-powered locomotive, the dream of a freight train fully powered by batteries remains elusive. The challenges of substituting diesel with batteries—primarily due to batteries' substantial weight and volume—make it an impractical solution for long-haul trains. Additionally, the risk of battery overheating and potential explosions, which can emit harmful gases, is a significant safety concern. As the editorial noted, "Even if the technology for zero-emission locomotives eventually arrives, railroads will have to test them over many years to guarantee their safety."
The cost-benefit analysis is woefully unfavorable to the forced displacement of diesel locomotives. To "help" the transition, beginning in 2026, CARB will force all railroads operating in California to deposit dollars into an escrow account managed by the state and frozen for the explicit pursuit of the green agenda. For large railroads, this figure will be a staggering $1.6 billion per year, whereas some smaller railroads will pay up to $5 million.
Many of these smaller companies have signaled that they will simply go out of business. For the large railroads, the requirement will lock up about 20 percent of annual spending, money typically used for maintenance and safety improvements.
Transportation is the largest source of U.S. emissions, yet railroads' contribution amounts to not much more than a rounding error. The industry cites its efficiency improvements over time, allowing railroads today to move a ton of freight more than 500 miles on a single gallon of diesel. Its expensive machines, which last between 30 to 50 years and are retrofitted throughout their life cycles, are about 75 percent more efficient than long-haul trucks that carry a comparative amount of freight.
As Patricia Patnode of the Competitive Enterprise Institute, which signed the aforementioned letter to the EPA, recently remarked, "Rather than abolish diesel trains, CARB should stand in awe of these marvels of energy-efficient transportation."
President Joe Biden talks a lot about trains, but his actions since taking office have consistently punished the private companies we should value far more than state-supported Amtrak. In this case, EPA Administrator Michael Regan and the White House need not think too hard. They should wait for reality to catch up before imposing on the rest of us one state's demands and ambitions.
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“How do we get to making nanomaterials that haven’t been evolved before?” asked Angela Belcher at the 2023 Mildred S. Dresselhaus Lecture at MIT on Nov. 20. “We can use elements that biology has already given us.”
The combined in-person and virtual audience of over 300 was treated to a light-up, 3D model of M13 bacteriophage, a virus that only infects bacteria, complete with a pull-out strand of DNA. Belcher used the feather-boa-like model to show how her research group modifies the M13’s genes to add new DNA and peptide sequences to template inorganic materials.
“I love controlling materials at the nanoscale using biology,” said Belcher, the James Mason Crafts Professor of Biological Engineering, materials science professor, and of the Koch Institute of Integrative Cancer Research at MIT. “We all know if you control materials at the nanoscale and you can start to tune them, then you can have all kinds of different applications.” And the opportunities are indeed vast — from building batteries, fuel cells, and solar cells to carbon sequestration and storage, environmental remediation, catalysis, and medical diagnostics and imaging.
Belcher sprinkled her talk with models and props, lined up on a table at the front of the 10-250 lecture hall, to demonstrate a wide variety of concepts and projects made possible by the intersection of biology and nanotechnology.
Energy storage and environment
“How do you go from a DNA sequence to a functioning battery?” posed Belcher. Grabbing a model of a large carbon nanotube, she explained how her group engineered a phage to pick up carbon nanotubes that would wind all the way around the virus and then fill in with different cathode or anode materials to make nanowires for battery electrodes.
How about using the M13 bacteriophage to improve the environment? Belcher referred to a project by former student Geran Zhang PhD ’19 that proved the virus can be modified for this context, too. He used the phage to template high-surface-area, carbon-based materials that can grab small molecules and break them down, Belcher said, opening a realm of possibilities from cleaning up rivers to developing chemical warfare agents to combating smog.
Belcher’s lab worked with the U.S. Army to produce protective clothing and masks made of these carbon-based virus nanofibers. “We went from five liters in our lab to a thousand liters, then 10,000 liters in the army labs where we’re able to make kilograms of the material,” Belcher said, stressing the importance of being able to test and prototype at scale.
Imaging tools and therapeutics in cancer
In the area of biomedical imaging, Belcher explained, a lot less is known in near-infrared imaging — imaging in wavelengths above 1,000 nanometers — than other imaging techniques, yet with near-infrared scientists can see much deeper inside the body. Belcher’s lab built their own systems to image at these wavelengths. The third generation of this system provides real-time, sub-millimeter optical imaging for guided surgery.
Working with Sangeeta Bhatia, the John J. and Dorothy Wilson Professor of Engineering, Belcher used carbon nanotubes to build imaging tools that find tiny tumors during surgery that doctors otherwise would not be able to see. The tool is actually a virus engineered to carry with it a fluorescent, single-walled carbon nanotube as it seeks out the tumors.
Nearing the end of her talk, Belcher presented a goal: to develop an accessible detection and diagnostic technology for ovarian cancer in five to 10 years.
“We think that we can do it,” Belcher said. She described her students’ work developing a way to scan an entire fallopian tube, as opposed to just one small portion, to find pre-cancer lesions, and talked about the team of MIT faculty, doctors, and researchers working collectively toward this goal.
“Part of the secret of life and the meaning of life is helping other people enjoy the passage of time,” said Belcher in her closing remarks. “I think that we can all do that by working to solve some of the biggest issues on the planet, including helping to diagnose and treat ovarian cancer early so people have more time to spend with their family.”
Honoring Mildred S. Dresselhaus
Belcher was the fifth speaker to deliver the Dresselhaus Lecture, an annual event organized by MIT.nano to honor the late MIT physics and electrical engineering Institute Professor Mildred Dresselhaus. The lecture features a speaker from anywhere in the world whose leadership and impact echo Dresselhaus’s life, accomplishments, and values.
“Millie was and is a huge hero of mine,” said Belcher. “Giving a lecture in Millie’s name is just the greatest honor.”
Belcher dedicated the talk to Dresselhaus, whom she described with an array of accolades — a trailblazer, a genius, an amazing mentor, teacher, and inventor. “Just knowing her was such a privilege,” she said.
Belcher also dedicated her talk to her own grandmother and mother, both of whom passed away from cancer, as well as late MIT professors Susan Lindquist and Angelika Amon, who both died of ovarian cancer.
“I’ve been so fortunate to work with just the most talented and dedicated graduate students, undergraduate students, postdocs, and researchers,” concluded Belcher. “It has been a pure joy to be in partnership with all of you to solve these very daunting problems.”
Professor Angela Belcher pulls a single strand of DNA out of a light-up model of M13 bacteriophage, a virus that only infects bacteria. Belcher’s lab modifies the M13’s genes to add new DNA and peptide sequences to template inorganic materials.
“How do we get to making nanomaterials that haven’t been evolved before?” asked Angela Belcher at the 2023 Mildred S. Dresselhaus Lecture at MIT on Nov. 20. “We can use elements that biology has already given us.”
The combined in-person and virtual audience of over 300 was treated to a light-up, 3D model of M13 bacteriophage, a virus that only infects bacteria, complete with a pull-out strand of DNA. Belcher used the feather-boa-like model to show how her research group modifies the M13’s genes to add new DNA and peptide sequences to template inorganic materials.
“I love controlling materials at the nanoscale using biology,” said Belcher, the James Mason Crafts Professor of Biological Engineering, materials science professor, and of the Koch Institute of Integrative Cancer Research at MIT. “We all know if you control materials at the nanoscale and you can start to tune them, then you can have all kinds of different applications.” And the opportunities are indeed vast — from building batteries, fuel cells, and solar cells to carbon sequestration and storage, environmental remediation, catalysis, and medical diagnostics and imaging.
Belcher sprinkled her talk with models and props, lined up on a table at the front of the 10-250 lecture hall, to demonstrate a wide variety of concepts and projects made possible by the intersection of biology and nanotechnology.
Energy storage and environment
“How do you go from a DNA sequence to a functioning battery?” posed Belcher. Grabbing a model of a large carbon nanotube, she explained how her group engineered a phage to pick up carbon nanotubes that would wind all the way around the virus and then fill in with different cathode or anode materials to make nanowires for battery electrodes.
How about using the M13 bacteriophage to improve the environment? Belcher referred to a project by former student Geran Zhang PhD ’19 that proved the virus can be modified for this context, too. He used the phage to template high-surface-area, carbon-based materials that can grab small molecules and break them down, Belcher said, opening a realm of possibilities from cleaning up rivers to developing chemical warfare agents to combating smog.
Belcher’s lab worked with the U.S. Army to produce protective clothing and masks made of these carbon-based virus nanofibers. “We went from five liters in our lab to a thousand liters, then 10,000 liters in the army labs where we’re able to make kilograms of the material,” Belcher said, stressing the importance of being able to test and prototype at scale.
Imaging tools and therapeutics in cancer
In the area of biomedical imaging, Belcher explained, a lot less is known in near-infrared imaging — imaging in wavelengths above 1,000 nanometers — than other imaging techniques, yet with near-infrared scientists can see much deeper inside the body. Belcher’s lab built their own systems to image at these wavelengths. The third generation of this system provides real-time, sub-millimeter optical imaging for guided surgery.
Working with Sangeeta Bhatia, the John J. and Dorothy Wilson Professor of Engineering, Belcher used carbon nanotubes to build imaging tools that find tiny tumors during surgery that doctors otherwise would not be able to see. The tool is actually a virus engineered to carry with it a fluorescent, single-walled carbon nanotube as it seeks out the tumors.
Nearing the end of her talk, Belcher presented a goal: to develop an accessible detection and diagnostic technology for ovarian cancer in five to 10 years.
“We think that we can do it,” Belcher said. She described her students’ work developing a way to scan an entire fallopian tube, as opposed to just one small portion, to find pre-cancer lesions, and talked about the team of MIT faculty, doctors, and researchers working collectively toward this goal.
“Part of the secret of life and the meaning of life is helping other people enjoy the passage of time,” said Belcher in her closing remarks. “I think that we can all do that by working to solve some of the biggest issues on the planet, including helping to diagnose and treat ovarian cancer early so people have more time to spend with their family.”
Honoring Mildred S. Dresselhaus
Belcher was the fifth speaker to deliver the Dresselhaus Lecture, an annual event organized by MIT.nano to honor the late MIT physics and electrical engineering Institute Professor Mildred Dresselhaus. The lecture features a speaker from anywhere in the world whose leadership and impact echo Dresselhaus’s life, accomplishments, and values.
“Millie was and is a huge hero of mine,” said Belcher. “Giving a lecture in Millie’s name is just the greatest honor.”
Belcher dedicated the talk to Dresselhaus, whom she described with an array of accolades — a trailblazer, a genius, an amazing mentor, teacher, and inventor. “Just knowing her was such a privilege,” she said.
Belcher also dedicated her talk to her own grandmother and mother, both of whom passed away from cancer, as well as late MIT professors Susan Lindquist and Angelika Amon, who both died of ovarian cancer.
“I’ve been so fortunate to work with just the most talented and dedicated graduate students, undergraduate students, postdocs, and researchers,” concluded Belcher. “It has been a pure joy to be in partnership with all of you to solve these very daunting problems.”
Professor Angela Belcher pulls a single strand of DNA out of a light-up model of M13 bacteriophage, a virus that only infects bacteria. Belcher’s lab modifies the M13’s genes to add new DNA and peptide sequences to template inorganic materials.
“How do we get to making nanomaterials that haven’t been evolved before?” asked Angela Belcher at the 2023 Mildred S. Dresselhaus Lecture at MIT on Nov. 20. “We can use elements that biology has already given us.”
The combined in-person and virtual audience of over 300 was treated to a light-up, 3D model of M13 bacteriophage, a virus that only infects bacteria, complete with a pull-out strand of DNA. Belcher used the feather-boa-like model to show how her research group modifies the M13’s genes to add new DNA and peptide sequences to template inorganic materials.
“I love controlling materials at the nanoscale using biology,” said Belcher, the James Mason Crafts Professor of Biological Engineering, materials science professor, and of the Koch Institute of Integrative Cancer Research at MIT. “We all know if you control materials at the nanoscale and you can start to tune them, then you can have all kinds of different applications.” And the opportunities are indeed vast — from building batteries, fuel cells, and solar cells to carbon sequestration and storage, environmental remediation, catalysis, and medical diagnostics and imaging.
Belcher sprinkled her talk with models and props, lined up on a table at the front of the 10-250 lecture hall, to demonstrate a wide variety of concepts and projects made possible by the intersection of biology and nanotechnology.
Energy storage and environment
“How do you go from a DNA sequence to a functioning battery?” posed Belcher. Grabbing a model of a large carbon nanotube, she explained how her group engineered a phage to pick up carbon nanotubes that would wind all the way around the virus and then fill in with different cathode or anode materials to make nanowires for battery electrodes.
How about using the M13 bacteriophage to improve the environment? Belcher referred to a project by former student Geran Zhang PhD ’19 that proved the virus can be modified for this context, too. He used the phage to template high-surface-area, carbon-based materials that can grab small molecules and break them down, Belcher said, opening a realm of possibilities from cleaning up rivers to developing chemical warfare agents to combating smog.
Belcher’s lab worked with the U.S. Army to produce protective clothing and masks made of these carbon-based virus nanofibers. “We went from five liters in our lab to a thousand liters, then 10,000 liters in the army labs where we’re able to make kilograms of the material,” Belcher said, stressing the importance of being able to test and prototype at scale.
Imaging tools and therapeutics in cancer
In the area of biomedical imaging, Belcher explained, a lot less is known in near-infrared imaging — imaging in wavelengths above 1,000 nanometers — than other imaging techniques, yet with near-infrared scientists can see much deeper inside the body. Belcher’s lab built their own systems to image at these wavelengths. The third generation of this system provides real-time, sub-millimeter optical imaging for guided surgery.
Working with Sangeeta Bhatia, the John J. and Dorothy Wilson Professor of Engineering, Belcher used carbon nanotubes to build imaging tools that find tiny tumors during surgery that doctors otherwise would not be able to see. The tool is actually a virus engineered to carry with it a fluorescent, single-walled carbon nanotube as it seeks out the tumors.
Nearing the end of her talk, Belcher presented a goal: to develop an accessible detection and diagnostic technology for ovarian cancer in five to 10 years.
“We think that we can do it,” Belcher said. She described her students’ work developing a way to scan an entire fallopian tube, as opposed to just one small portion, to find pre-cancer lesions, and talked about the team of MIT faculty, doctors, and researchers working collectively toward this goal.
“Part of the secret of life and the meaning of life is helping other people enjoy the passage of time,” said Belcher in her closing remarks. “I think that we can all do that by working to solve some of the biggest issues on the planet, including helping to diagnose and treat ovarian cancer early so people have more time to spend with their family.”
Honoring Mildred S. Dresselhaus
Belcher was the fifth speaker to deliver the Dresselhaus Lecture, an annual event organized by MIT.nano to honor the late MIT physics and electrical engineering Institute Professor Mildred Dresselhaus. The lecture features a speaker from anywhere in the world whose leadership and impact echo Dresselhaus’s life, accomplishments, and values.
“Millie was and is a huge hero of mine,” said Belcher. “Giving a lecture in Millie’s name is just the greatest honor.”
Belcher dedicated the talk to Dresselhaus, whom she described with an array of accolades — a trailblazer, a genius, an amazing mentor, teacher, and inventor. “Just knowing her was such a privilege,” she said.
Belcher also dedicated her talk to her own grandmother and mother, both of whom passed away from cancer, as well as late MIT professors Susan Lindquist and Angelika Amon, who both died of ovarian cancer.
“I’ve been so fortunate to work with just the most talented and dedicated graduate students, undergraduate students, postdocs, and researchers,” concluded Belcher. “It has been a pure joy to be in partnership with all of you to solve these very daunting problems.”
Professor Angela Belcher pulls a single strand of DNA out of a light-up model of M13 bacteriophage, a virus that only infects bacteria. Belcher’s lab modifies the M13’s genes to add new DNA and peptide sequences to template inorganic materials.
By mining data from X-ray images, researchers at MIT, Stanford University, SLAC National Accelerator, and the Toyota Research Institute have made significant new discoveries about the reactivity of lithium iron phosphate, a material used in batteries for electric cars and in other rechargeable batteries.
The new technique has revealed several phenomena that were previously impossible to see, including variations in the rate of lithium intercalation reactions in different regions of a lithium iron phosphate nanoparticle.
The paper’s most significant practical finding — that these variations in reaction rate are correlated with differences in the thickness of the carbon coating on the surface of the particles — could lead to improvements in the efficiency of charging and discharging such batteries.
“What we learned from this study is that it’s the interfaces that really control the dynamics of the battery, especially in today’s modern batteries made from nanoparticles of the active material. That means that our focus should really be on engineering that interface,” says Martin Bazant, the E.G. Roos Professor of Chemical Engineering and a professor of mathematics at MIT, who is the senior author of the study.
This approach to discovering the physics behind complex patterns in images could also be used to gain insights into many other materials, not only other types of batteries but also biological systems, such as dividing cells in a developing embryo.
“What I find most exciting about this work is the ability to take images of a system that’s undergoing the formation of some pattern, and learning the principles that govern that,” Bazant says.
Hongbo Zhao PhD ’21, a former MIT graduate student who is now a postdoc at Princeton University, is the lead author of the new study, which appears today in Nature. Other authors include Richard Bratz, the Edwin R. Gilliland Professor of Chemical Engineering at MIT; William Chueh, an associate professor of materials science and engineering at Stanford and director of the SLAC-Stanford Battery Center; and Brian Storey, senior director of Energy and Materials at the Toyota Research Institute.
“Until now, we could make these beautiful X-ray movies of battery nanoparticles at work, but it was challenging to measure and understand subtle details of how they function because the movies were so information-rich,” Chueh says. “By applying image learning to these nanoscale movies, we can extract insights that were not previously possible.”
Modeling reaction rates
Lithium iron phosphate battery electrodes are made of many tiny particles of lithium iron phosphate, surrounded by an electrolyte solution. A typical particle is about 1 micron in diameter and about 100 nanometers thick. When the battery discharges, lithium ions flow from the electrolyte solution into the material by an electrochemical reaction known as ion intercalation. When the battery charges, the intercalation reaction is reversed, and ions flow in the opposite direction.
“Lithium iron phosphate (LFP) is an important battery material due to low cost, a good safety record, and its use of abundant elements,” Storey says. “We are seeing an increased use of LFP in the EV market, so the timing of this study could not be better.”
Before the current study, Bazant had done a great deal of theoretical modeling of patterns formed by lithium-ion intercalation. Lithium iron phosphate prefers to exist in one of two stable phases: either full of lithium ions or empty. Since 2005, Bazant has been working on mathematical models of this phenomenon, known as phase separation, which generates distinctive patterns of lithium-ion flow driven by intercalation reactions. In 2015, while on sabbatical at Stanford, he began working with Chueh to try to interpret images of lithium iron phosphate particles from scanning transmission X-ray microscopy.
Using this type of microscopy, the researchers can obtain images that reveal the concentration of lithium ions, pixel-by-pixel, at every point in the particle. They can scan the particles several times as the particles charge or discharge, allowing them to create movies of how lithium ions flow in and out of the particles.
In 2017, Bazant and his colleagues at SLAC received funding from the Toyota Research Institute to pursue further studies using this approach, along with other battery-related research projects.
By analyzing X-ray images of 63 lithium iron phosphate particles as they charged and discharged, the researchers found that the movement of lithium ions within the material could be nearly identical to the computer simulations that Bazant had created earlier. Using all 180,000 pixels as measurements, the researchers trained the computational model to produce equations that accurately describe the nonequilibrium thermodynamics and reaction kinetics of the battery material.
“Every little pixel in there is jumping from full to empty, full to empty. And we’re mapping that whole process, using our equations to understand how that’s happening,” Bazant says.
The researchers also found that the patterns of lithium-ion flow that they observed could reveal spatial variations in the rate at which lithium ions are absorbed at each location on the particle surface.
“It was a real surprise to us that we could learn the heterogeneities in the system — in this case, the variations in surface reaction rate — simply by looking at the images,” Bazant says. “There are regions that seem to be fast and others that seem to be slow.”
Furthermore, the researchers showed that these differences in reaction rate were correlated with the thickness of the carbon coating on the surface of the lithium iron phosphate particles. That carbon coating is applied to lithium iron phosphate to help it conduct electricity — otherwise the material would conduct too slowly to be useful as a battery.
“We discovered at the nano scale that variation of the carbon coating thickness directly controls the rate, which is something you could never figure out if you didn't have all of this modeling and image analysis,” Bazant says.
The findings also offer quantitative support for a hypothesis Bazant formulated several years ago: that the performance of lithium iron phosphate electrodes is limited primarily by the rate of coupled ion-electron transfer at the interface between the solid particle and the carbon coating, rather than the rate of lithium-ion diffusion in the solid.
Optimized materials
The results from this study suggest that optimizing the thickness of the carbon layer on the electrode surface could help researchers to design batteries that would work more efficiently, the researchers say.
“This is the first study that's been able to directly attribute a property of the battery material with a physical property of the coating,” Bazant says. “The focus for optimizing and designing batteries should be on controlling reaction kinetics at the interface of the electrolyte and electrode.”
“This publication is the culmination of six years of dedication and collaboration,” Storey says. “This technique allows us to unlock the inner workings of the battery in a way not previously possible. Our next goal is to improve battery design by applying this new understanding.”
In addition to using this type of analysis on other battery materials, Bazant anticipates that it could be useful for studying pattern formation in other chemical and biological systems.
This work was supported by the Toyota Research Institute through the Accelerated Materials Design and Discovery program.
By mining X-ray images, MIT researchers have made significant new discoveries about the reactivity of lithium iron phosphate, a material used in batteries for electric cars and in other rechargeable batteries. In each pair pictured, actual particles are on the left and the researchers’ simulations are on the right.
“How do we get to making nanomaterials that haven’t been evolved before?” asked Angela Belcher at the 2023 Mildred S. Dresselhaus Lecture at MIT on Nov. 20. “We can use elements that biology has already given us.”
The combined in-person and virtual audience of over 300 was treated to a light-up, 3D model of M13 bacteriophage, a virus that only infects bacteria, complete with a pull-out strand of DNA. Belcher used the feather-boa-like model to show how her research group modifies the M13’s genes to add new DNA and peptide sequences to template inorganic materials.
“I love controlling materials at the nanoscale using biology,” said Belcher, the James Mason Crafts Professor of Biological Engineering, materials science professor, and of the Koch Institute of Integrative Cancer Research at MIT. “We all know if you control materials at the nanoscale and you can start to tune them, then you can have all kinds of different applications.” And the opportunities are indeed vast — from building batteries, fuel cells, and solar cells to carbon sequestration and storage, environmental remediation, catalysis, and medical diagnostics and imaging.
Belcher sprinkled her talk with models and props, lined up on a table at the front of the 10-250 lecture hall, to demonstrate a wide variety of concepts and projects made possible by the intersection of biology and nanotechnology.
Energy storage and environment
“How do you go from a DNA sequence to a functioning battery?” posed Belcher. Grabbing a model of a large carbon nanotube, she explained how her group engineered a phage to pick up carbon nanotubes that would wind all the way around the virus and then fill in with different cathode or anode materials to make nanowires for battery electrodes.
How about using the M13 bacteriophage to improve the environment? Belcher referred to a project by former student Geran Zhang PhD ’19 that proved the virus can be modified for this context, too. He used the phage to template high-surface-area, carbon-based materials that can grab small molecules and break them down, Belcher said, opening a realm of possibilities from cleaning up rivers to developing chemical warfare agents to combating smog.
Belcher’s lab worked with the U.S. Army to produce protective clothing and masks made of these carbon-based virus nanofibers. “We went from five liters in our lab to a thousand liters, then 10,000 liters in the army labs where we’re able to make kilograms of the material,” Belcher said, stressing the importance of being able to test and prototype at scale.
Imaging tools and therapeutics in cancer
In the area of biomedical imaging, Belcher explained, a lot less is known in near-infrared imaging — imaging in wavelengths above 1,000 nanometers — than other imaging techniques, yet with near-infrared scientists can see much deeper inside the body. Belcher’s lab built their own systems to image at these wavelengths. The third generation of this system provides real-time, sub-millimeter optical imaging for guided surgery.
Working with Sangeeta Bhatia, the John J. and Dorothy Wilson Professor of Engineering, Belcher used carbon nanotubes to build imaging tools that find tiny tumors during surgery that doctors otherwise would not be able to see. The tool is actually a virus engineered to carry with it a fluorescent, single-walled carbon nanotube as it seeks out the tumors.
Nearing the end of her talk, Belcher presented a goal: to develop an accessible detection and diagnostic technology for ovarian cancer in five to 10 years.
“We think that we can do it,” Belcher said. She described her students’ work developing a way to scan an entire fallopian tube, as opposed to just one small portion, to find pre-cancer lesions, and talked about the team of MIT faculty, doctors, and researchers working collectively toward this goal.
“Part of the secret of life and the meaning of life is helping other people enjoy the passage of time,” said Belcher in her closing remarks. “I think that we can all do that by working to solve some of the biggest issues on the planet, including helping to diagnose and treat ovarian cancer early so people have more time to spend with their family.”
Honoring Mildred S. Dresselhaus
Belcher was the fifth speaker to deliver the Dresselhaus Lecture, an annual event organized by MIT.nano to honor the late MIT physics and electrical engineering Institute Professor Mildred Dresselhaus. The lecture features a speaker from anywhere in the world whose leadership and impact echo Dresselhaus’s life, accomplishments, and values.
“Millie was and is a huge hero of mine,” said Belcher. “Giving a lecture in Millie’s name is just the greatest honor.”
Belcher dedicated the talk to Dresselhaus, whom she described with an array of accolades — a trailblazer, a genius, an amazing mentor, teacher, and inventor. “Just knowing her was such a privilege,” she said.
Belcher also dedicated her talk to her own grandmother and mother, both of whom passed away from cancer, as well as late MIT professors Susan Lindquist and Angelika Amon, who both died of ovarian cancer.
“I’ve been so fortunate to work with just the most talented and dedicated graduate students, undergraduate students, postdocs, and researchers,” concluded Belcher. “It has been a pure joy to be in partnership with all of you to solve these very daunting problems.”
Professor Angela Belcher pulls a single strand of DNA out of a light-up model of M13 bacteriophage, a virus that only infects bacteria. Belcher’s lab modifies the M13’s genes to add new DNA and peptide sequences to template inorganic materials.
By mining data from X-ray images, researchers at MIT, Stanford University, SLAC National Accelerator, and the Toyota Research Institute have made significant new discoveries about the reactivity of lithium iron phosphate, a material used in batteries for electric cars and in other rechargeable batteries.
The new technique has revealed several phenomena that were previously impossible to see, including variations in the rate of lithium intercalation reactions in different regions of a lithium iron phosphate nanoparticle.
The paper’s most significant practical finding — that these variations in reaction rate are correlated with differences in the thickness of the carbon coating on the surface of the particles — could lead to improvements in the efficiency of charging and discharging such batteries.
“What we learned from this study is that it’s the interfaces that really control the dynamics of the battery, especially in today’s modern batteries made from nanoparticles of the active material. That means that our focus should really be on engineering that interface,” says Martin Bazant, the E.G. Roos Professor of Chemical Engineering and a professor of mathematics at MIT, who is the senior author of the study.
This approach to discovering the physics behind complex patterns in images could also be used to gain insights into many other materials, not only other types of batteries but also biological systems, such as dividing cells in a developing embryo.
“What I find most exciting about this work is the ability to take images of a system that’s undergoing the formation of some pattern, and learning the principles that govern that,” Bazant says.
Hongbo Zhao PhD ’21, a former MIT graduate student who is now a postdoc at Princeton University, is the lead author of the new study, which appears today in Nature. Other authors include Richard Bratz, the Edwin R. Gilliland Professor of Chemical Engineering at MIT; William Chueh, an associate professor of materials science and engineering at Stanford and director of the SLAC-Stanford Battery Center; and Brian Storey, senior director of Energy and Materials at the Toyota Research Institute.
“Until now, we could make these beautiful X-ray movies of battery nanoparticles at work, but it was challenging to measure and understand subtle details of how they function because the movies were so information-rich,” Chueh says. “By applying image learning to these nanoscale movies, we can extract insights that were not previously possible.”
Modeling reaction rates
Lithium iron phosphate battery electrodes are made of many tiny particles of lithium iron phosphate, surrounded by an electrolyte solution. A typical particle is about 1 micron in diameter and about 100 nanometers thick. When the battery discharges, lithium ions flow from the electrolyte solution into the material by an electrochemical reaction known as ion intercalation. When the battery charges, the intercalation reaction is reversed, and ions flow in the opposite direction.
“Lithium iron phosphate (LFP) is an important battery material due to low cost, a good safety record, and its use of abundant elements,” Storey says. “We are seeing an increased use of LFP in the EV market, so the timing of this study could not be better.”
Before the current study, Bazant had done a great deal of theoretical modeling of patterns formed by lithium-ion intercalation. Lithium iron phosphate prefers to exist in one of two stable phases: either full of lithium ions or empty. Since 2005, Bazant has been working on mathematical models of this phenomenon, known as phase separation, which generates distinctive patterns of lithium-ion flow driven by intercalation reactions. In 2015, while on sabbatical at Stanford, he began working with Chueh to try to interpret images of lithium iron phosphate particles from scanning transmission X-ray microscopy.
Using this type of microscopy, the researchers can obtain images that reveal the concentration of lithium ions, pixel-by-pixel, at every point in the particle. They can scan the particles several times as the particles charge or discharge, allowing them to create movies of how lithium ions flow in and out of the particles.
In 2017, Bazant and his colleagues at SLAC received funding from the Toyota Research Institute to pursue further studies using this approach, along with other battery-related research projects.
By analyzing X-ray images of 63 lithium iron phosphate particles as they charged and discharged, the researchers found that the movement of lithium ions within the material could be nearly identical to the computer simulations that Bazant had created earlier. Using all 180,000 pixels as measurements, the researchers trained the computational model to produce equations that accurately describe the nonequilibrium thermodynamics and reaction kinetics of the battery material.
“Every little pixel in there is jumping from full to empty, full to empty. And we’re mapping that whole process, using our equations to understand how that’s happening,” Bazant says.
The researchers also found that the patterns of lithium-ion flow that they observed could reveal spatial variations in the rate at which lithium ions are absorbed at each location on the particle surface.
“It was a real surprise to us that we could learn the heterogeneities in the system — in this case, the variations in surface reaction rate — simply by looking at the images,” Bazant says. “There are regions that seem to be fast and others that seem to be slow.”
Furthermore, the researchers showed that these differences in reaction rate were correlated with the thickness of the carbon coating on the surface of the lithium iron phosphate particles. That carbon coating is applied to lithium iron phosphate to help it conduct electricity — otherwise the material would conduct too slowly to be useful as a battery.
“We discovered at the nano scale that variation of the carbon coating thickness directly controls the rate, which is something you could never figure out if you didn't have all of this modeling and image analysis,” Bazant says.
The findings also offer quantitative support for a hypothesis Bazant formulated several years ago: that the performance of lithium iron phosphate electrodes is limited primarily by the rate of coupled ion-electron transfer at the interface between the solid particle and the carbon coating, rather than the rate of lithium-ion diffusion in the solid.
Optimized materials
The results from this study suggest that optimizing the thickness of the carbon layer on the electrode surface could help researchers to design batteries that would work more efficiently, the researchers say.
“This is the first study that's been able to directly attribute a property of the battery material with a physical property of the coating,” Bazant says. “The focus for optimizing and designing batteries should be on controlling reaction kinetics at the interface of the electrolyte and electrode.”
“This publication is the culmination of six years of dedication and collaboration,” Storey says. “This technique allows us to unlock the inner workings of the battery in a way not previously possible. Our next goal is to improve battery design by applying this new understanding.”
In addition to using this type of analysis on other battery materials, Bazant anticipates that it could be useful for studying pattern formation in other chemical and biological systems.
This work was supported by the Toyota Research Institute through the Accelerated Materials Design and Discovery program.
By mining X-ray images, MIT researchers have made significant new discoveries about the reactivity of lithium iron phosphate, a material used in batteries for electric cars and in other rechargeable batteries. In each pair pictured, actual particles are on the left and the researchers’ simulations are on the right.
“How do we get to making nanomaterials that haven’t been evolved before?” asked Angela Belcher at the 2023 Mildred S. Dresselhaus Lecture at MIT on Nov. 20. “We can use elements that biology has already given us.”
The combined in-person and virtual audience of over 300 was treated to a light-up, 3D model of M13 bacteriophage, a virus that only infects bacteria, complete with a pull-out strand of DNA. Belcher used the feather-boa-like model to show how her research group modifies the M13’s genes to add new DNA and peptide sequences to template inorganic materials.
“I love controlling materials at the nanoscale using biology,” said Belcher, the James Mason Crafts Professor of Biological Engineering, materials science professor, and of the Koch Institute of Integrative Cancer Research at MIT. “We all know if you control materials at the nanoscale and you can start to tune them, then you can have all kinds of different applications.” And the opportunities are indeed vast — from building batteries, fuel cells, and solar cells to carbon sequestration and storage, environmental remediation, catalysis, and medical diagnostics and imaging.
Belcher sprinkled her talk with models and props, lined up on a table at the front of the 10-250 lecture hall, to demonstrate a wide variety of concepts and projects made possible by the intersection of biology and nanotechnology.
Energy storage and environment
“How do you go from a DNA sequence to a functioning battery?” posed Belcher. Grabbing a model of a large carbon nanotube, she explained how her group engineered a phage to pick up carbon nanotubes that would wind all the way around the virus and then fill in with different cathode or anode materials to make nanowires for battery electrodes.
How about using the M13 bacteriophage to improve the environment? Belcher referred to a project by former student Geran Zhang PhD ’19 that proved the virus can be modified for this context, too. He used the phage to template high-surface-area, carbon-based materials that can grab small molecules and break them down, Belcher said, opening a realm of possibilities from cleaning up rivers to developing chemical warfare agents to combating smog.
Belcher’s lab worked with the U.S. Army to produce protective clothing and masks made of these carbon-based virus nanofibers. “We went from five liters in our lab to a thousand liters, then 10,000 liters in the army labs where we’re able to make kilograms of the material,” Belcher said, stressing the importance of being able to test and prototype at scale.
Imaging tools and therapeutics in cancer
In the area of biomedical imaging, Belcher explained, a lot less is known in near-infrared imaging — imaging in wavelengths above 1,000 nanometers — than other imaging techniques, yet with near-infrared scientists can see much deeper inside the body. Belcher’s lab built their own systems to image at these wavelengths. The third generation of this system provides real-time, sub-millimeter optical imaging for guided surgery.
Working with Sangeeta Bhatia, the John J. and Dorothy Wilson Professor of Engineering, Belcher used carbon nanotubes to build imaging tools that find tiny tumors during surgery that doctors otherwise would not be able to see. The tool is actually a virus engineered to carry with it a fluorescent, single-walled carbon nanotube as it seeks out the tumors.
Nearing the end of her talk, Belcher presented a goal: to develop an accessible detection and diagnostic technology for ovarian cancer in five to 10 years.
“We think that we can do it,” Belcher said. She described her students’ work developing a way to scan an entire fallopian tube, as opposed to just one small portion, to find pre-cancer lesions, and talked about the team of MIT faculty, doctors, and researchers working collectively toward this goal.
“Part of the secret of life and the meaning of life is helping other people enjoy the passage of time,” said Belcher in her closing remarks. “I think that we can all do that by working to solve some of the biggest issues on the planet, including helping to diagnose and treat ovarian cancer early so people have more time to spend with their family.”
Honoring Mildred S. Dresselhaus
Belcher was the fifth speaker to deliver the Dresselhaus Lecture, an annual event organized by MIT.nano to honor the late MIT physics and electrical engineering Institute Professor Mildred Dresselhaus. The lecture features a speaker from anywhere in the world whose leadership and impact echo Dresselhaus’s life, accomplishments, and values.
“Millie was and is a huge hero of mine,” said Belcher. “Giving a lecture in Millie’s name is just the greatest honor.”
Belcher dedicated the talk to Dresselhaus, whom she described with an array of accolades — a trailblazer, a genius, an amazing mentor, teacher, and inventor. “Just knowing her was such a privilege,” she said.
Belcher also dedicated her talk to her own grandmother and mother, both of whom passed away from cancer, as well as late MIT professors Susan Lindquist and Angelika Amon, who both died of ovarian cancer.
“I’ve been so fortunate to work with just the most talented and dedicated graduate students, undergraduate students, postdocs, and researchers,” concluded Belcher. “It has been a pure joy to be in partnership with all of you to solve these very daunting problems.”
Professor Angela Belcher pulls a single strand of DNA out of a light-up model of M13 bacteriophage, a virus that only infects bacteria. Belcher’s lab modifies the M13’s genes to add new DNA and peptide sequences to template inorganic materials.
By mining data from X-ray images, researchers at MIT, Stanford University, SLAC National Accelerator, and the Toyota Research Institute have made significant new discoveries about the reactivity of lithium iron phosphate, a material used in batteries for electric cars and in other rechargeable batteries.
The new technique has revealed several phenomena that were previously impossible to see, including variations in the rate of lithium intercalation reactions in different regions of a lithium iron phosphate nanoparticle.
The paper’s most significant practical finding — that these variations in reaction rate are correlated with differences in the thickness of the carbon coating on the surface of the particles — could lead to improvements in the efficiency of charging and discharging such batteries.
“What we learned from this study is that it’s the interfaces that really control the dynamics of the battery, especially in today’s modern batteries made from nanoparticles of the active material. That means that our focus should really be on engineering that interface,” says Martin Bazant, the E.G. Roos Professor of Chemical Engineering and a professor of mathematics at MIT, who is the senior author of the study.
This approach to discovering the physics behind complex patterns in images could also be used to gain insights into many other materials, not only other types of batteries but also biological systems, such as dividing cells in a developing embryo.
“What I find most exciting about this work is the ability to take images of a system that’s undergoing the formation of some pattern, and learning the principles that govern that,” Bazant says.
Hongbo Zhao PhD ’21, a former MIT graduate student who is now a postdoc at Princeton University, is the lead author of the new study, which appears today in Nature. Other authors include Richard Bratz, the Edwin R. Gilliland Professor of Chemical Engineering at MIT; William Chueh, an associate professor of materials science and engineering at Stanford and director of the SLAC-Stanford Battery Center; and Brian Storey, senior director of Energy and Materials at the Toyota Research Institute.
“Until now, we could make these beautiful X-ray movies of battery nanoparticles at work, but it was challenging to measure and understand subtle details of how they function because the movies were so information-rich,” Chueh says. “By applying image learning to these nanoscale movies, we can extract insights that were not previously possible.”
Modeling reaction rates
Lithium iron phosphate battery electrodes are made of many tiny particles of lithium iron phosphate, surrounded by an electrolyte solution. A typical particle is about 1 micron in diameter and about 100 nanometers thick. When the battery discharges, lithium ions flow from the electrolyte solution into the material by an electrochemical reaction known as ion intercalation. When the battery charges, the intercalation reaction is reversed, and ions flow in the opposite direction.
“Lithium iron phosphate (LFP) is an important battery material due to low cost, a good safety record, and its use of abundant elements,” Storey says. “We are seeing an increased use of LFP in the EV market, so the timing of this study could not be better.”
Before the current study, Bazant had done a great deal of theoretical modeling of patterns formed by lithium-ion intercalation. Lithium iron phosphate prefers to exist in one of two stable phases: either full of lithium ions or empty. Since 2005, Bazant has been working on mathematical models of this phenomenon, known as phase separation, which generates distinctive patterns of lithium-ion flow driven by intercalation reactions. In 2015, while on sabbatical at Stanford, he began working with Chueh to try to interpret images of lithium iron phosphate particles from scanning transmission X-ray microscopy.
Using this type of microscopy, the researchers can obtain images that reveal the concentration of lithium ions, pixel-by-pixel, at every point in the particle. They can scan the particles several times as the particles charge or discharge, allowing them to create movies of how lithium ions flow in and out of the particles.
In 2017, Bazant and his colleagues at SLAC received funding from the Toyota Research Institute to pursue further studies using this approach, along with other battery-related research projects.
By analyzing X-ray images of 63 lithium iron phosphate particles as they charged and discharged, the researchers found that the movement of lithium ions within the material could be nearly identical to the computer simulations that Bazant had created earlier. Using all 180,000 pixels as measurements, the researchers trained the computational model to produce equations that accurately describe the nonequilibrium thermodynamics and reaction kinetics of the battery material.
“Every little pixel in there is jumping from full to empty, full to empty. And we’re mapping that whole process, using our equations to understand how that’s happening,” Bazant says.
The researchers also found that the patterns of lithium-ion flow that they observed could reveal spatial variations in the rate at which lithium ions are absorbed at each location on the particle surface.
“It was a real surprise to us that we could learn the heterogeneities in the system — in this case, the variations in surface reaction rate — simply by looking at the images,” Bazant says. “There are regions that seem to be fast and others that seem to be slow.”
Furthermore, the researchers showed that these differences in reaction rate were correlated with the thickness of the carbon coating on the surface of the lithium iron phosphate particles. That carbon coating is applied to lithium iron phosphate to help it conduct electricity — otherwise the material would conduct too slowly to be useful as a battery.
“We discovered at the nano scale that variation of the carbon coating thickness directly controls the rate, which is something you could never figure out if you didn't have all of this modeling and image analysis,” Bazant says.
The findings also offer quantitative support for a hypothesis Bazant formulated several years ago: that the performance of lithium iron phosphate electrodes is limited primarily by the rate of coupled ion-electron transfer at the interface between the solid particle and the carbon coating, rather than the rate of lithium-ion diffusion in the solid.
Optimized materials
The results from this study suggest that optimizing the thickness of the carbon layer on the electrode surface could help researchers to design batteries that would work more efficiently, the researchers say.
“This is the first study that's been able to directly attribute a property of the battery material with a physical property of the coating,” Bazant says. “The focus for optimizing and designing batteries should be on controlling reaction kinetics at the interface of the electrolyte and electrode.”
“This publication is the culmination of six years of dedication and collaboration,” Storey says. “This technique allows us to unlock the inner workings of the battery in a way not previously possible. Our next goal is to improve battery design by applying this new understanding.”
In addition to using this type of analysis on other battery materials, Bazant anticipates that it could be useful for studying pattern formation in other chemical and biological systems.
This work was supported by the Toyota Research Institute through the Accelerated Materials Design and Discovery program.
By mining X-ray images, MIT researchers have made significant new discoveries about the reactivity of lithium iron phosphate, a material used in batteries for electric cars and in other rechargeable batteries. In each pair pictured, actual particles are on the left and the researchers’ simulations are on the right.
E-bikes are today a growing component of the global transition away from fossil fuels—possibly more than the car-and-truck-focused sustainability crowd appreciates. E-bikes’ rapid growth in recent years stems in part from their simple solution to the range issue that big, hulking cars typically don’t offer. E-bikes are powered by relatively small batteries that can be wrangled by the average person who can handle a carton of milk.
Because of that form factor, battery swapping for e-bikes is a quick and simple method for staying powered up, whereas for a traditional four-wheeled EV, swaps are a more involved process for doing the equivalent of filling a gas tank.
The Japanese conglomerate Yamaha Motor Co., best known for its motorcycles and motorboats, is now looking to expand into this growing marketplace, too. At the end of last year, Yamaha announced it’d formed a subsidiary called Enyring. The new entity, which is slated to kick off operations in Germany and the Netherlands in early 2025, says they’ll partner with manufacturers for maximum compatibility among models and types of e-bike. Also crucial to Yamaha’s plan is that the batteries will not be owned, but rented, by the e-bike owners. The rental contract will entitle a battery user to unlimited swaps as long as their account with Yamaha remains in good standing. And Yamaha says it already has plans in place for breaking down the cells so they can be recycled.
“Today, noisy, polluting, two-stroke gasoline engines are still ubiquitous across Asia,” says Sam Abuelsamid, Principal Research Analyst for Mobility Ecosystems at Guidehouse Insights “Converting those to electric power will go a long way toward helping countries reach their greenhouse gas emission-reduction targets. Battery swapping also addresses the infrastructure issues that come along with the growing presence of two- and three-wheeled vehicles.”
Abuelsamid notes that as this energy-replenishing modality becomes the norm, companies like Yamaha, China’s Nio, and Taiwan’s Gogoro (the latter two with hundreds of battery-swapping stations and self-service swapping kiosks already in operation) will raise the bar on quality control for these small EV batteries for their own economic self-interest.
“It makes sense to build better batteries with good battery management systems and software for enhanced thermal control,” says Abuelsamid. “Higher-quality batteries, handled in an ecosystem where corporate facilities manage the recharging process better than someone would at home, increases the chances that a battery will handle maybe 1,000 charge cycles before it no longer holds enough charge and needs to be recycled.” And longer life means more profitability for a company offering batteries-as-a-service.
According to analysis firm Markets and Markets, battery swapping was a US $1.7 billion industry in 2022. Industry revenues are expected to reach $11.8 billion by 2027. Yamaha is by no means a battery-swapping pioneer, but its entry into that space signals a powerful retort to skeptics who still believe that battery swapping will never be as commonplace as pulling up to a charging facility and plugging in. (However, attempts to reach Yamaha spokespeople for their comment on the Enyring spinoff proved unsuccessful.)
The enticing growth in the compact EV market has been spurred by the near ubiquitous use of e-bikes and electric scooters by couriers for delivery services that drop take-out food and groceries at online shoppers’ doors. Plus, for daily commutes, e-bikes are proving increasingly attractive as eco-friendly alternatives to fossil-fueled vehicles. Battery-swapping ventures like Yamaha’s will also put salve on pain points related to the rapidly growing presence of compact EVs. Among these are: a shortage of places where batteries can be charged; the length of time (now measured in hours) charging usually takes; human error when charging that could cause destructive, and perhaps deadly, battery fires; and uncertainty about what to do with a battery when it is spent and is no longer useful as an energy storage unit for propulsion.
Just as important is what battery swapping will do to solve another of plug-in electric vehicles’ bugbears. IEEE Spectrum reported on the issues surrounding battery charging and the lingering belief that EV batteries are fire hazards. Though empirical evidence shows that EVs, by and large, are much less likely than vehicles with internal combustion engines to catch fire, that hasn’t stopped some municipal governments from placing strict limits on the places where EV batteries can be plugged in. But with battery swapping growing in popularity, who would ultimately need to?
“How do we get to making nanomaterials that haven’t been evolved before?” asked Angela Belcher at the 2023 Mildred S. Dresselhaus Lecture at MIT on Nov. 20. “We can use elements that biology has already given us.”
The combined in-person and virtual audience of over 300 was treated to a light-up, 3D model of M13 bacteriophage, a virus that only infects bacteria, complete with a pull-out strand of DNA. Belcher used the feather-boa-like model to show how her research group modifies the M13’s genes to add new DNA and peptide sequences to template inorganic materials.
“I love controlling materials at the nanoscale using biology,” said Belcher, the James Mason Crafts Professor of Biological Engineering, materials science professor, and of the Koch Institute of Integrative Cancer Research at MIT. “We all know if you control materials at the nanoscale and you can start to tune them, then you can have all kinds of different applications.” And the opportunities are indeed vast — from building batteries, fuel cells, and solar cells to carbon sequestration and storage, environmental remediation, catalysis, and medical diagnostics and imaging.
Belcher sprinkled her talk with models and props, lined up on a table at the front of the 10-250 lecture hall, to demonstrate a wide variety of concepts and projects made possible by the intersection of biology and nanotechnology.
Energy storage and environment
“How do you go from a DNA sequence to a functioning battery?” posed Belcher. Grabbing a model of a large carbon nanotube, she explained how her group engineered a phage to pick up carbon nanotubes that would wind all the way around the virus and then fill in with different cathode or anode materials to make nanowires for battery electrodes.
How about using the M13 bacteriophage to improve the environment? Belcher referred to a project by former student Geran Zhang PhD ’19 that proved the virus can be modified for this context, too. He used the phage to template high-surface-area, carbon-based materials that can grab small molecules and break them down, Belcher said, opening a realm of possibilities from cleaning up rivers to developing chemical warfare agents to combating smog.
Belcher’s lab worked with the U.S. Army to produce protective clothing and masks made of these carbon-based virus nanofibers. “We went from five liters in our lab to a thousand liters, then 10,000 liters in the army labs where we’re able to make kilograms of the material,” Belcher said, stressing the importance of being able to test and prototype at scale.
Imaging tools and therapeutics in cancer
In the area of biomedical imaging, Belcher explained, a lot less is known in near-infrared imaging — imaging in wavelengths above 1,000 nanometers — than other imaging techniques, yet with near-infrared scientists can see much deeper inside the body. Belcher’s lab built their own systems to image at these wavelengths. The third generation of this system provides real-time, sub-millimeter optical imaging for guided surgery.
Working with Sangeeta Bhatia, the John J. and Dorothy Wilson Professor of Engineering, Belcher used carbon nanotubes to build imaging tools that find tiny tumors during surgery that doctors otherwise would not be able to see. The tool is actually a virus engineered to carry with it a fluorescent, single-walled carbon nanotube as it seeks out the tumors.
Nearing the end of her talk, Belcher presented a goal: to develop an accessible detection and diagnostic technology for ovarian cancer in five to 10 years.
“We think that we can do it,” Belcher said. She described her students’ work developing a way to scan an entire fallopian tube, as opposed to just one small portion, to find pre-cancer lesions, and talked about the team of MIT faculty, doctors, and researchers working collectively toward this goal.
“Part of the secret of life and the meaning of life is helping other people enjoy the passage of time,” said Belcher in her closing remarks. “I think that we can all do that by working to solve some of the biggest issues on the planet, including helping to diagnose and treat ovarian cancer early so people have more time to spend with their family.”
Honoring Mildred S. Dresselhaus
Belcher was the fifth speaker to deliver the Dresselhaus Lecture, an annual event organized by MIT.nano to honor the late MIT physics and electrical engineering Institute Professor Mildred Dresselhaus. The lecture features a speaker from anywhere in the world whose leadership and impact echo Dresselhaus’s life, accomplishments, and values.
“Millie was and is a huge hero of mine,” said Belcher. “Giving a lecture in Millie’s name is just the greatest honor.”
Belcher dedicated the talk to Dresselhaus, whom she described with an array of accolades — a trailblazer, a genius, an amazing mentor, teacher, and inventor. “Just knowing her was such a privilege,” she said.
Belcher also dedicated her talk to her own grandmother and mother, both of whom passed away from cancer, as well as late MIT professors Susan Lindquist and Angelika Amon, who both died of ovarian cancer.
“I’ve been so fortunate to work with just the most talented and dedicated graduate students, undergraduate students, postdocs, and researchers,” concluded Belcher. “It has been a pure joy to be in partnership with all of you to solve these very daunting problems.”
Professor Angela Belcher pulls a single strand of DNA out of a light-up model of M13 bacteriophage, a virus that only infects bacteria. Belcher’s lab modifies the M13’s genes to add new DNA and peptide sequences to template inorganic materials.
By mining data from X-ray images, researchers at MIT, Stanford University, SLAC National Accelerator, and the Toyota Research Institute have made significant new discoveries about the reactivity of lithium iron phosphate, a material used in batteries for electric cars and in other rechargeable batteries.
The new technique has revealed several phenomena that were previously impossible to see, including variations in the rate of lithium intercalation reactions in different regions of a lithium iron phosphate nanoparticle.
The paper’s most significant practical finding — that these variations in reaction rate are correlated with differences in the thickness of the carbon coating on the surface of the particles — could lead to improvements in the efficiency of charging and discharging such batteries.
“What we learned from this study is that it’s the interfaces that really control the dynamics of the battery, especially in today’s modern batteries made from nanoparticles of the active material. That means that our focus should really be on engineering that interface,” says Martin Bazant, the E.G. Roos Professor of Chemical Engineering and a professor of mathematics at MIT, who is the senior author of the study.
This approach to discovering the physics behind complex patterns in images could also be used to gain insights into many other materials, not only other types of batteries but also biological systems, such as dividing cells in a developing embryo.
“What I find most exciting about this work is the ability to take images of a system that’s undergoing the formation of some pattern, and learning the principles that govern that,” Bazant says.
Hongbo Zhao PhD ’21, a former MIT graduate student who is now a postdoc at Princeton University, is the lead author of the new study, which appears today in Nature. Other authors include Richard Bratz, the Edwin R. Gilliland Professor of Chemical Engineering at MIT; William Chueh, an associate professor of materials science and engineering at Stanford and director of the SLAC-Stanford Battery Center; and Brian Storey, senior director of Energy and Materials at the Toyota Research Institute.
“Until now, we could make these beautiful X-ray movies of battery nanoparticles at work, but it was challenging to measure and understand subtle details of how they function because the movies were so information-rich,” Chueh says. “By applying image learning to these nanoscale movies, we can extract insights that were not previously possible.”
Modeling reaction rates
Lithium iron phosphate battery electrodes are made of many tiny particles of lithium iron phosphate, surrounded by an electrolyte solution. A typical particle is about 1 micron in diameter and about 100 nanometers thick. When the battery discharges, lithium ions flow from the electrolyte solution into the material by an electrochemical reaction known as ion intercalation. When the battery charges, the intercalation reaction is reversed, and ions flow in the opposite direction.
“Lithium iron phosphate (LFP) is an important battery material due to low cost, a good safety record, and its use of abundant elements,” Storey says. “We are seeing an increased use of LFP in the EV market, so the timing of this study could not be better.”
Before the current study, Bazant had done a great deal of theoretical modeling of patterns formed by lithium-ion intercalation. Lithium iron phosphate prefers to exist in one of two stable phases: either full of lithium ions or empty. Since 2005, Bazant has been working on mathematical models of this phenomenon, known as phase separation, which generates distinctive patterns of lithium-ion flow driven by intercalation reactions. In 2015, while on sabbatical at Stanford, he began working with Chueh to try to interpret images of lithium iron phosphate particles from scanning transmission X-ray microscopy.
Using this type of microscopy, the researchers can obtain images that reveal the concentration of lithium ions, pixel-by-pixel, at every point in the particle. They can scan the particles several times as the particles charge or discharge, allowing them to create movies of how lithium ions flow in and out of the particles.
In 2017, Bazant and his colleagues at SLAC received funding from the Toyota Research Institute to pursue further studies using this approach, along with other battery-related research projects.
By analyzing X-ray images of 63 lithium iron phosphate particles as they charged and discharged, the researchers found that the movement of lithium ions within the material could be nearly identical to the computer simulations that Bazant had created earlier. Using all 180,000 pixels as measurements, the researchers trained the computational model to produce equations that accurately describe the nonequilibrium thermodynamics and reaction kinetics of the battery material.
“Every little pixel in there is jumping from full to empty, full to empty. And we’re mapping that whole process, using our equations to understand how that’s happening,” Bazant says.
The researchers also found that the patterns of lithium-ion flow that they observed could reveal spatial variations in the rate at which lithium ions are absorbed at each location on the particle surface.
“It was a real surprise to us that we could learn the heterogeneities in the system — in this case, the variations in surface reaction rate — simply by looking at the images,” Bazant says. “There are regions that seem to be fast and others that seem to be slow.”
Furthermore, the researchers showed that these differences in reaction rate were correlated with the thickness of the carbon coating on the surface of the lithium iron phosphate particles. That carbon coating is applied to lithium iron phosphate to help it conduct electricity — otherwise the material would conduct too slowly to be useful as a battery.
“We discovered at the nano scale that variation of the carbon coating thickness directly controls the rate, which is something you could never figure out if you didn't have all of this modeling and image analysis,” Bazant says.
The findings also offer quantitative support for a hypothesis Bazant formulated several years ago: that the performance of lithium iron phosphate electrodes is limited primarily by the rate of coupled ion-electron transfer at the interface between the solid particle and the carbon coating, rather than the rate of lithium-ion diffusion in the solid.
Optimized materials
The results from this study suggest that optimizing the thickness of the carbon layer on the electrode surface could help researchers to design batteries that would work more efficiently, the researchers say.
“This is the first study that's been able to directly attribute a property of the battery material with a physical property of the coating,” Bazant says. “The focus for optimizing and designing batteries should be on controlling reaction kinetics at the interface of the electrolyte and electrode.”
“This publication is the culmination of six years of dedication and collaboration,” Storey says. “This technique allows us to unlock the inner workings of the battery in a way not previously possible. Our next goal is to improve battery design by applying this new understanding.”
In addition to using this type of analysis on other battery materials, Bazant anticipates that it could be useful for studying pattern formation in other chemical and biological systems.
This work was supported by the Toyota Research Institute through the Accelerated Materials Design and Discovery program.
By mining X-ray images, MIT researchers have made significant new discoveries about the reactivity of lithium iron phosphate, a material used in batteries for electric cars and in other rechargeable batteries. In each pair pictured, actual particles are on the left and the researchers’ simulations are on the right.
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Jess M. Ritchie demonstrates his AD-X2 battery additive before the Senate Select Committee on Small Business.National Institute of Standards and Technology Digital Collections
AD-X2 consisted mainly of Epsom salt and Glauber’s salt.National Institute of Standards and Technology Digital Collections
The National Bureau of Standards’ regular tests of battery additives found that the products did not work as claimed.National Institute of Standards and Technology Digital Collections
National Bureau of Standards director Edward Condon [left] resigned in 1951 because investigations into his political beliefs were impeding his ability to represent the bureau. Incoming director Allen V. Astin [right] inherited the AD-X2 controversy, which eventually led to Astin’s dismissal and then his reinstatement after a large-scale protest by NBS researchers and others. National Institute of Standards and Technology Digital Collections
